Table 2.
The significant subpathways identified by ce‐Subpathway using PAH data set
| Subpathway ID | PathwayName | ce‐Subpathway | Hypergeometric | Gene set enrichment analysis | SPIA | Subpathway‐GM | Reference(PMID) |
|---|---|---|---|---|---|---|---|
| path:04010_2 | MAPK signalling pathway | 0 | 0.0054 | — | — | — | 27688788; 28055284 |
| path:04510_12# | Focal adhesion | 6.03E‐10 | — | — | — | — | 22293597; 28077433; 27274622 |
| path:04110_5# | Cell cycle | 7.61E‐09 | — | — | — | — | 27470556; 27581840; 26273643 |
| path:04722_2 | Neurotrophin signalling pathway | 7.61E‐09 | 0.0093 | — | — | — | 24462831 |
| path:04910_2# | Insulin signalling pathway | 3.33E‐08 | — | — | — | — | 26254106; 25921925 |
| path:04210_9 | Apoptosis | 2.00E‐07 | 0.0310 | — | 0.0368 | — | 28068653; 28036116 |
| path:04062_6 | Chemokine signalling pathway | 3.37E‐07 | 0.0339 | — | 0.0026 | — | 28393260; 28774332 |
| path:04720_3# | Long‐term potentiation | 3.37E‐07 | — | — | — | — | 18704488 |
| path:04070_1# | Phosphatidylinositol signalling system | 9.24E‐07 | — | — | — | — | 24084215; 23220709; 29074487 |
| path:04630_2# | Jak‐STAT signalling pathway | 1.85E‐06 | — | — | — | — | 24058777; 24058763; 28393260 |
| path:04930_1# | Type II diabetes mellitus | 1.85E‐06 | — | — | — | — | 16304314; 23348820 |
| path:04110_3# | Cell cycle | 3.81E‐06 | — | — | — | — | 27470556; 27581840; 26273643 |
| path:04310_20# | Wnt signalling pathway | 4.32E‐06 | — | — | — | — | 27188753; 26860892 |
| path:00562_1# | Inositol phosphate metabolism | 6.68E‐06 | — | — | — | — | 9847264; 15838259; 23077657 |
| path:04630_6# | Jak‐STAT signalling pathway | 9.18E‐06 | — | — | — | — | 24058777; 24058763; 28393260 |
| path:04810_5# | Regulation of actin cytoskeleton | 1.15E‐05 | — | — | — | — | 24283363; 19188659; 29473816 |
| path:04350_21# | TGF‐β signalling pathway | 1.20E‐05 | — | — | — | — | 24956016; 18202349 |
| path:04620_14 | Toll‐like receptor signalling pathway | 2.19E‐05 | 2.62E‐05 | — | 2.73E‐05 | — | 27418552; 26418144; 27712004 |
| path:04150_3# | mTOR signalling pathway | 3.67E‐05 | — | — | — | — | 27258250; 26409044 |
| path:04810_19# | Regulation of actin cytoskeleton | 3.71E‐05 | — | — | — | — | 24283363; 19188659; 29473816 |
| path:04114_1# | Oocyte meiosis | 3.71E‐05 | — | — | — | — | 20886366 |
| path:04670_7# | Leucocyte transendothelial migration | 6.64E‐05 | — | — | — | — | 25909334; 25722443 |
| path:00230_8# | Purine metabolism | 6.64E‐05 | — | — | — | — | 24656288 |
| path:04115_5# | p53 signalling pathway | 0.0001 | — | — | — | — | 27063355; 25290246 |
| path:04020_1# | Calcium signalling pathway | 0.0004 | — | — | — | — | 23300272; 15838259; 24770445; 23739180 |
| path:04664_4# | Fc epsilon RI signalling pathway | 0.0004 | — | — | — | — | na |
| path:04510_10# | Focal adhesion | 0.0008 | — | — | — | — | 22293597; 28077433; 27274622 |
| path:04621_1 | NOD‐like receptor signalling pathway | 0.0008 | 0.0009 | — | 0.0034 | 6.42E‐05 | 24736319 |
| path:00020_2# | Citrate cycle (TCA cycle) | 0.0026 | — | — | — | — | 23964055; 24533144 |
| path:04010_12 | MAPK signalling pathway | 0.0031 | 0.0054 | — | — | — | 27688788; 28055284 |
| path:00564_13# | Glycerophospholipid metabolism | 0.0035 | — | — | — | — | 26675529 |
Subpathways with # symbol are uniquely identified by ce‐Subpathway. The table lists FDR adjusted P‐values.