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. 2018 Nov 28;23(2):1439–1447. doi: 10.1111/jcmm.14049

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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Construction of a 4‐mRNA signature. (A) Fifty‐six mRNAs selected by univariate analysis. Volcano plot illustrating a comparison of mRNAs expression in BC with metastasis‐free and metastasis. (B) Hierarchical clustering shows the collinearity of 26 candidate mRNAs. (C) LASSO algorithms was used to identify and evaluate the 4‐mRNA signature in the training cohort. Four mRNAs were selected and used to develop a 4‐mRNA signature to predict patients prognosis. (D) LASSO coefficient profiles of the 26 metastasis and prognostic‐related mRNAs based on the training data (GSE20685)