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. 2018 Nov 16;23(2):798–810. doi: 10.1111/jcmm.13975

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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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VLD inhibits high glucose‐induced mitochondrial fission by regulation of dynamin‐related proteins. A, Effects of VLD on the expression of Drp1 and Fis1 in mice aortas. B, Effect of vildagliptin on the expression of Drp1 and Fis1 in HUVECs. C, Effect of VLD on Drp1 recruitment from cytoplasm to mitochondria. Data shown are mean ± SD (n = 3‐6). *P<0.05 vs the normal group; ^# P < 0.05 vs the HG group or the diabetic control group. VLD, vildagliptin; HUVECs, human umbilical vein endothelial cells; HG, high glucose; Man, mannitol