Figure 6.

Inhibition of Drp1 attenuates ROS and mtROS production and increases NO generation in diabetic mice. MtROS, ROS, and NO production in vascular were determined as described in Figures 1 and 2. A‐D, Effect of mdivi‐1 on vascular mtROS, ROS, and NO production in mice. E, Effects of Drp1 knockdown on the levels of 8‐OHdG and 3‐NT in mice aortas. Data shown represent mean ± SD (n = 6). *P < 0.05 vs the diabetic control group. ROS, reactive oxygen species; mtROS, mitochondrial reactive oxygen species; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; peNOS, phosphorylation of eNOS at Ser1177