Figure 5.

Schematic representation of a critical molecular mechanism by which HOXA‐AS2 regulates osteogenesis. HOXA‐AS2 plays an inhibitory effect on NF‐κB activity by repressing the K310 acetylation status of RelA. Once HOXA‐AS2 becomes dysfunctional, the NF‐κB will be activated and recruited to the promoter of master transcription factor SP7, co‐activating the deacetylase HDAC2. The HDAC2 will then contribute to the deacetylation of H3K27, consequently leading to the transcriptional repression of SP7