Table 1.
CXXC‐type zinc‐finger protein family in human
| Member | Alias | Length (aa) | Catalytic activity |
|---|---|---|---|
| CXXC1 | CGBP, CFP1 | 660 | H3K4 methyltransferase |
| CXXC2 | KDM2B, FBXL10 | 1336 | H3K36 demethylase |
| CXXC3 | MBD1 | 605 | Interacts with and recruits the H3K9 methyltransferase SETDB1 |
| CXXC4 | IDAX | 367 | Interacts with and recruits TET2 |
| CXXC5 | RINF, WID | 322 | Interacts with and recruits TET2 |
| CXXC6 | TET1, LCX | 2136 | 5‐methylcytosine dioxygenase |
| CXXC7 | MLL1, KMT2A | 3969 | H3K4 methyltransferase |
| CXXC8 | KDM2A, JHDM1a, FBXL11 | 1162 | H3K36 demethylase |
| CXXC9 | DNMT1 | 1616 | DNA methyltransferase |
| CXXC10 | MLL2, KMT2B | 2715 | H3K4 methyltransferase |
| CXXC11 | FBXL19 | 694 | A component of the Skp1‐Cullin‐F‐box family of E3 ubiquitin ligases |
| TET3 | 1660 | 5‐methylcytosine dioxygenase |