Table 2.
Genes directly regulated by CXXC5
| Gene | Regulation by CXXC5 | Function | References |
|---|---|---|---|
| IRF7 | Up | Contributes to TLR7/9‐ and virus‐induced IFN responses | 5 |
| MBP | Up | Promotes differentiation of neural stem cells into oligodendrocytes | 20 |
| Flk‐1 | Up | Promotes endothelial cell differentiation, migration and vessel formation | 7 |
| MCK, MHC | Up | Promotes skeletal muscle differentiation | 21 |
| Cd40L | Down | Inhibits differentiation into helper‐lineage T cells | 22 |
| COX4I2 | Down | Inhibits energy production in hypoxic conditions | 6 |
MBP, myelin basic protein; MCK, muscle creatine kinase; MHC, myosin heavy chain.