Table 3.
Interacting partners of CXXC5 protein
| Interacting partner | Interaction site | Functional consequence of the interaction | References |
|---|---|---|---|
| Dishevelled | Cytoplasm | Inhibits Wnt/β‐catenin signaling | 8, 9, 11, 61 |
| HDAC1 | Nd. | Removes HDAC1 from Smad2/3 and promotes TGF‐β signaling | 10 |
| Smad2/3/4 | Predominantly nucleus | Mediates TNF‐α‐induced apoptosis and regulates zebrafish heart development | 49, 50 |
| ATM | Mainly nucleus | Contributes to p53 activation and DNA damage response | 12 |
| VDR | Nd. | Stimulates VDR transcriptional activity | 66 |
| SUV39H1 | Nd. | Represses CD40 ligand expression in CD8+ cytotoxic T cells | 22 |
| RBPJ | Nd. | Inhibits COX4I2 gene transcription | 6 |
| Tet2 | Nucleus | Contributes to IFN response by activating IRF7 expression | 5 |
Nd., not determined; ATM, ataxia telangiectasia mutated; VDR, vitamin D receptor; TGF‐β, transforming growth factor beta.