Table 4.
Transcriptional regulation of the CXXC5 gene
| Cytokine or transcription factor | CXXC5 expression | Cell type and context | References |
|---|---|---|---|
| TGF‐β | Up | Hepatocellular carcinoma cells and normal liver cells | 10 |
| BMP4 | Up | Embryonic neural stem cells, endothelial cells and HUVECs | 7, 11 |
| Wnt3a/β‐catenin | Up | Pre‐osteoblast MC3T3E1 cells, human dermal fibroblasts and neural stem cells | 8, 9, 20 |
| E2/ERα | Up | Breast cancer cells | 82 |
| Retinoid/RARα | Up | NB4 myeloid cells | 3 |
| WT1 | Up | Zebrafish embryonic kidney development | 61 |
| KANK1 | Up | Embryonic kidney | 79 |
| GATA2 | Up | Acute myeloid leukemia | 71 |
| ThPOK | Down | CD8+ cytotoxic T cells | 22 |
| NUDT21 | Down | Liver cancer cells | 83 |
TGF‐β, transforming growth factor beta; BMPs, bone and morphogenetic proteins.