Table 2.
MiRNA plasma levels in blood donors and type 2 diabetic patients
| MiRNA | Blood donors (n = 20) | Without DR (n = 91) | P valueb | NPDR (n = 46) | PDR (n = 49) | P valuec |
|---|---|---|---|---|---|---|
| miR‐29b (log2 FC) | –1.79 (−2.14 to −1.19) | –1.16 (−2.32 to −0.35) | 0.073 | –1.66 (−2.89 to −0.27) | –1.91 (−2.54 to −1.23)d | 0.022 |
| miR‐200b (log2 FC)a | 0.68 (0.10‐0.92) | –0.41 (−1.11 to 0.67) | 0.001 | –0.69 (−1.64 to 0.07) | –0.91 (−1.98 to 0.09) | 0.078 |
Data are shown as median (25th‐75th percentiles).
FC, fold change.
a
Data available for 179 type 2 diabetic patients (four patients without DR, one with NPDR and two with PDR had undetectable levels).
b
Comparison of diabetic patients without DR and blood donors.
c
Comparison of diabetic patients with PDR, NPDR and without DR.
d
Significantly different from the group without DR after correction for pairwise multiple comparisons (P < 0.05, Tukey test).