Table 3.
Univariate and multiple logistic regression analysis for the association between miRNA levels and PDR
| Variable | Univariate model | Multivariate model | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| miR‐29b (log2 FC) | 0.694 (0.535‐0.900) | 0.006 | 0.720 (0.420‐1.233) | 0.231 |
| miR‐200b (log2 FC) | 0.797 (0.637‐0.997) | 0.047 | 1.166 (0.757‐1.796) | 0.486 |
| Male gender | 3.211 (1.560‐6.609) | 0.002 | 1.231 (0.410‐3.698) | 0.711 |
| Age (y) | 1.060 (1.011‐1.112) | 0.016 | 1.038 (0.952‐1.131) | 0.401 |
| Diabetes duration (y) | 1.077 (1.029‐1.127) | 0.001 | 1.022 (0.950‐1.100) | 0.557 |
| Hypertension (yes/no) | 0.309 (0.125‐0.762) | 0.011 | 0.312 (0.075‐1.293) | 0.108 |
| Body mass index (kg/m2) | 0.865 (0.793‐0.943) | 0.001 | 0.887 (0.794‐0.992) | 0.035 |
| Insulin use (yes/no) | 3.494 (1.558‐7.834) | 0.002 | 3.461 (0.882‐13.589) | 0.075 |
| eGFR (mL/min/1.73 m2) | 0.965 (0.948‐0.982) | <0.001 | 0.966 (0.942‐0.991) | 0.007 |
OR, odds ratio; CI, confidence interval; FC, fold change; eGFR, estimated glomerular filtration rate.