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. Author manuscript; available in PMC: 2019 Jan 28.
Published in final edited form as: Pharmacol Ther. 2013 Dec 9;142(2):154–163. doi: 10.1016/j.pharmthera.2013.12.003

Fig 2. The roles of FAK in lipid-mediated tumor growth and invasion.

Fig 2.

FAK interactions with receptors such as IR/IGF1R/integrin and effectors such as PI3K/Akt/ERK are associated with lipid rafts. Formation and translocation of FAK-associated lipid complexes contributes to ACLY and FASN activation, channeling TCA-processed glucose to promote lipogenesis. Excessive lipid biosynthesis can induce cell growth and lipid turnover-mediated motility. Inhibition of ACLY and FASN leads to decreased lipid biosynthesis and tumor growth/invasion.

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