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. 2019 Jan 15;12(3):561–575. doi: 10.1016/j.tranon.2018.12.011

Figure 5.

Figure 5

PKC activation leads to an increase in claudin 1 expression in several breast cancer cell lines but to a decrease in the nontumorigenic MDCKII cell line. Cells were treated with 100 nM TPA or vehicle control (DMSO) for 18 hours. Western blots of a representative experiment are shown for each cell line (left panels). The relative protein levels were determined by densitometry (right panels, mean ± SD for experimental replicates). (A) MCF7 cells; n=6. (B) MDA-MB231 cells; n=5. (C) BT-20 cells; n=4. (D) MDCKII cells, n=4. *P<.05; Student’s t test.