Figure 8.

Activation of PKC leads to a decrease in E-cadherin and β-catenin levels in MCF7 cells. Cells were treated with 100 nM TPA or vehicle control (DMSO) for 18 hours. Western blots of a representative experiment are shown for each cell line (left panels). The relative protein levels were determined by densitometry (right panels, mean ± SD for experimental replicates). (A) E-cadherin; n=4. (B) β-catenin; n=4. *P<.05; **P<.01; Student’s t test.