Fig 7. Effect of analogue 3a on B. atrox venom myotoxicity in vitro, and lapachol and its analogues 3a and 3b in vivo.

Panel A shows EDL muscle superfused with B. atrox venom (25 μ/mL) alone or associated with analogue 3a (300 μM) (n = 4). Two-Way ANOVA Bonferroni’s post-hoc test. Panel B shows plasma CK 2 h after i.m. injection (0.1 mL) of B. atrox venom (V) alone or associated with lapachol (1), analogue 3a or 3b (30 mg/kg) (n = 5). One-way ANOVA Dunnett’s post-hoc test.