Figure 2.

MiR‐552 promoted hepatocellular carcinoma (HCC) cell proliferation, migration and invasion. (A) In both Hep3B and HepG2 cells, miR‐552 was overexpressed in cells transfected with miR‐552 mimics. The cells in the mimic control group showed no significant difference compared with the NC group. **, P < 0.01 compared to the NC group. (B) In both Hep3B and HepG2 cells, miR‐552 was down‐regulated in cells transfected with miR‐552 inhibitors. The cells in the inhibitor control group showed no significant difference compared with the NC group. **, P < 0.01 compared to the NC group. (C) CCK8 assay results indicated that miR‐552 mimics led to a higher absorbance at OD 450 nm while the miR‐552 inhibitor led to a reduced absorbance in both Hep3B and HepG2 cells. *, P < 0.05, **, P < 0.01 compared to the NC group. (D, E) Transwell assay results showed that miR‐552 mimics promoted both migration and invasion in selected HCC cell lines, whereas the miR‐552 inhibitor acted as a suppressor. **, P < 0.01 compared to the control group