Table 8.
Histology data in counts of mice with observed lesions
| Renal Lesions | Hepatic Lesions | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | N | THP | KM | TD | MII | FM | INI | ANY RENAL LESION | DGN | MFI | ANY HEPATIC LESION |
| Control | 16 | 9 | 0 | 4 | 0 | 0 | 0 | 9 | 2 | 2 | 2 |
| 102 dB Noise | 7 | 5 | 0 | 2 | 1 | 0 | 0 | 6 | 1 | 2 | 2 |
| 105 dB Noise* | 10 | 9 | 0 | 5 | 1 | 0 | 0 | 9 | 1 | 1 | 1 |
| 108 dB Noise | 7 | 3 | 1 | 4 | 1 | 0 | 1 | 4 | 0 | 0 | 0 |
| 30 μM Cd | 6 | 4 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 0 |
| 100 μM Cd | 7 | 6 | 0 | 4 | 1 | 0 | 0 | 6 | 1 | 1 | 2 |
| 300 μM Cd* | 12 | 9 | 0 | 6 | 1 | 0 | 0 | 9 | 1 | 1 | 1 |
| Cd+Noise | 9 | 5 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 |
| 0.03 mM Pb | 8 | 8 | 0 | 3 | 0 | 0 | 0 | 8 | 1 | 1 | 1 |
| l mM Pb | 8 | 7 | 1 | 4 | 0 | 0 | 1 | 7 | 2 | 2 | 2 |
| 3 mM Pb* | 11 | 9 | 10 | 6 | 0 | 0 | 10 | 11 | 0 | 0 | 0 |
| Pb+Noise | 9 | 8 | 9 | 1 | 0 | 4 | 8 | 9 | 0 | 1 | 1 |
| Cd+Pb | 9 | 7 | 9 | 1 | 0 | 0 | 9 | 9 | 0 | 1 | 1 |
| Cd+Pb+Noise | 7 | 6 | 6 | 0 | 0 | 2 | 6 | 7 | 0 | 0 | 0 |
*
Group treatment levels used for mixtures (3 mM Pb, 300 μM Cd, & 105 dB Noise)
DGN - degeneration and necrosis, centrilobular and random
FM - focal mineralization
INI - intranuclear inclusions
KM - karyomegaly, tubular epithelium, S3
MFI - multifocal neutrophilic and mononuclear inflammation
MII - mononuclear interstitial inflammation
TD - tubular degeneration
THP - simple tubular hyperplasia