Table 1.
Percentage loading of pazopanib in self-assembled dipeptide nanotubes using pre and post-loading methods, after different incubation periods. The drug loading was measured by dissolving the nanosystems in DMSO and estimating the drug concentration by HPLC. PZB-NT-Pre: pazopanib loaded nanotubes by pre-loading method; PZB-NT-Post: pazopanib loaded nanotubes by post-loading method.
| S.No | Nanotube Formulation |
Incubation Time (Hrs) |
Drug Loading (% w/w) |
Loading Efficiency (%) |
|---|---|---|---|---|
| 1 | PZB-NT-Pre | 24 | 10 ± 0.8 | 22.4 ± 1.8 |
| 2 | PZB-NT-Post | 24 | 2.6 ± 0.2 | 5.8 ± 0.4 |
| 3 | PZB-NT-Pre | 48 | 24.9 ± 3.8 | 55.3 ± 8.4 |
| 4 | PZB-NT-Post | 48 | 7.6 ± 0.01 | 17 ± 0.02 |