Table 2.

Amount of pazopanib recovered from different ocular tissues like retina, choroid–RPE, sclera, vitreous humor, lens, cornea and from nanotubes at the end of 15 days. Mean weights of tissues isolated for drug analysis are reported. Actual tissue weights may be higher due to incomplete isolation of some tissues. Mean tissue weights reported in this table were multiplied by the mean tissue concentrations of pazopanib (µg/g tissue) to obtain total drug amounts in various tissues. Total administered drug dose was 50 µg each in nanotubular and dispersion samples. Data is expressed as mean for n=3.

Sample	Average tissue weight (mg)	Amount of pazopanib after 15 days (µg)
		Nanotube	Dispersion
Retina	10.72 ± 1.47	1.15 ± 0.06	0.23 ± 0.00
Choroid-RPE	5.05 ± 0.89	0.24 ± 0.04	0.10 ± 0.01
Vitreous	26.82 ± 3.61	0.29 ± 0.01	0.06 ± 0.00
Sclera	12.57 ± 2.23	0.16 ± 0.03	0.04 ± 0.01
Lens	28.46 ± 2.96	0.08 ± 0.01	0.01 ± 0.00
Aqueous Humor	7.01 ± 1.36	0.001 ± 0.00	0.000 ± 0.00
Cornea	4.85 ± 2.56	0.002 ± 0.00	0.000 ± 0.00
Total drug recovered in all the ocular tissues analyzed		2 (4.4 %)	0.45 (0.9%)