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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Curr Stem Cell Rep. 2018 Jul 13;4(3):189–200. doi: 10.1007/s40778-018-0131-y

Fig. 1: Molecular network controlling the interplay between HSCs and its inflammatory environment.

Fig. 1:

(a) Direct and indirect HSC response to inflammation. Low concentration of circulating pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) can directly affect the function of the HSCs, which express corresponding pattern recognition receptors (PRRs). PAMPs and DAMPs also alter the activity of immune cells and non-hematopoietic cells that form the bone marrow niche, leading to indirect modulation to the HSC compartment. (b) Consequences of inflammatory signaling on the HSC compartment. Direct and indirect inflammatory signals impact the HSC long-term fitness by instructing particular cell fate decision or promoting the selection of specific HSC subsets.