Table 1.
Cytotoxic activities of compounds 3a-m and doxorubicin against two cancerous cell lines; MDA-MB-231 and MCF-7
| |||
|---|---|---|---|
| No. | R | IC50 (µM)a
|
|
| MDA-MB-231 | MCF-7 | ||
|
| |||
| 3a |
|
10.2±2.2 | <60 |
| 3b |
|
5.5±2.2 | 11.7±1.8 |
| 3c |
|
54.8±5.7 | <60 |
| 3d |
|
11.9±3.5 | 35.7±7.1 |
| 3e |
|
3.3±0.8 | 4.2±2.1 |
| 3f |
|
<60 | <60 |
| 3g |
|
<60 | <60 |
| 3h |
|
6.1±1.1 | 8.6±1.4 |
| 3i |
|
21.7±2.3 | <60 |
| 3j |
|
2.6±0.6 | 8.4±5.7 |
| 3k |
|
22.2±0.5 | 18.7±5.6 |
| 3l |
|
37.8±4.2 | 29.7±1.1 |
| 3m |
|
25.2±7.5 | 45±8.1 |
| Doxorubicin | NA | 2.3±0.3 | 2.9±0.1 |
Notes:
a
Result of MTT assay after 48-hour drug treatment. Compounds tested in triplicate, data expressed as mean values of independent experiments ± standard error of the mean.
Abbreviation: NA, not available.