Table 2. Key studies on inter-organ preconditioning.

Study (RIPC Site)	Species	Target organ	Result
Renal
McClanahan et al. [227]	Rabbit	Heart	↓Infarct size
Gho et al. [22]	Rat	Heart	↓Infarct size
Verdouw et al. [228]	Pig	Heart	↓Infarct size
Pell et al. [229]	Rabbit	Heart	↓Infarct size
Takaoka et al.[52]	Rabbit	Heart	↓Infarct size and improved myocardial energy metabolism
Diwan et al. [230]	Rat	Heart	Conferred cardioprotection by NFkB activation followed by opening of K(ATP) channels
Lang et al. [32]	Rat	Heart	↓Infarct size
Singh et al. [231]	Rat	Heart	↓Infarct size and proposed the involvement of angiotensin AT(1) receptors in renal preconditioning
Kant et al. [232]	Rat	Heart	Reduced myocardial injury through inhibition of hypoxia inducible factor-prolyl 4-hydroxylases
Small Intestine
Gho et al. [22]	Rat	Heart	↓Infarct size
Verdouw et al. [228]	Pig	Heart	↓Infarct size
Patel et al. [233]	Rat	Heart	↓Infarct size
Heidbreder et al.[234]	Rat	Heart	↓Infarct size and activated p38 MAPK, ERK ½ and JNK ½ selectively in the intestine but not in the heart
Liver
Ates et al. [235]	Rat	Kidney	Improved creatine clearance and improvement in hepatic histopathologic parameters
Brzozowski et al. [236]	Rat	Gut	Reduced gastric mucosa lesion
Brain
Tapuria et al. [237]	Rat	Liver	Improved hepatic microcirculation and reduced hepatic I/R injury.
Hind Limb
Oxman et al. [238]	Rat	Heart	Decreased arrhythmias
Birnbaum et al.[239]	Rabbit	Heart	Reduced MI size
Liauw et al. [13]	Rat	Thigh muscle	Reduced muscle necrosis
Kharbanda et al.[14]	Pig	Heart	Reduced MI size
Gunaydin et al. [240]	Human	Heart	Enhanced anaerobic glycolysis to protect heart
Xia et al. [241]	Sheep	Lung	Protected lung from repeated coronary artery occlusion (CAO) and reperfusion mimicking multi-vessel off-pump coronary artery bypass (OPCAB) revascularization and decreased pulmonary vascular resistance
Addison et al. [242]	Pig	Skeletal muscle	Protected global skeletal muscle against infarction
Kuntscher et al. [243]	Rat	Adipocutaneous flaps	Decreased flap necrosis
Kuntscher et al. [244]	Rat	Cremasteric muscle flaps	Decreased flap necrosis
Kuntscher et al. [245]	Rat	Epigastric adipocutaneous flaps	Decreased flap necrosis
Moses et al. [246]	Pig	Latissimus dorsi (LD) muscle flaps	Decreased flap infarction
Wang et al. [247]	Rat	Cremaster flap	Decreased flap necrosis
Harkin et al. [248]	Pig	Lung	Reduced acute remote lung damage against systemic inflammatory response from limb I/R injury
Li et al. [249]	Mice	Heart	Protected LV function and reduced infarction size
Konstantinov et al. [24]	Pig	Heart	Reduced I/R injury in the brain-dead donor heart following orthotopic heart transplantation.
Chen et al. [250]	Rat	Heart	Reduced infarction size
Chen et al. [251]	Rat	Heart	Reduced infarction size through free radical pathway
Luokogeorgakis et al. [252]	Human	Forearm	Preserved endothelial function in the forearm
Waldow et al. [253]	Pig	Lung	Protected lung function and reduced the plasma interleukin-1beta level
Kristiansen et al. [254]	Rat	Heart	Reduced MI size through a mechanism involving mitochondrial K(ATP) channels and improved LV function during reperfusion
Zhang et al. [255]	Rat	Heart	Reduced infarction size and I/R-induced plasma lactate dehydrogenase level
Dave et al. [256]	Rat	Heart	Increased neuroprotection from asphyxial cardiac arrest
Kanoria et al. [257]	Rabbit	Liver	Reduced liver I/R injury and improved liver function
Lai et al. [258]	Rat	Liver	RIPC stimulated heme oxygenase-1 expression in liver tissue and associated with liver protection from I/R injury
Cheung et al. [259]	Human	Heart	Postoperative improvement in lung function and reduction in plasma troponin-I level
Mudaliar et al. [260]	Rat	Heart	↓ Infarct size through JAK-STAT pathway upregulation

Note: CAO: coronary artery occlusion, OCABG: off-pump coronary artery bypass, LV: left ventricular