Table 3.

Hazard ratios of stroke by different levels of high-density lipoprotein cholesterol at baseline among subpopulation of patients with type 2 diabetes

	High-density lipoprotein cholesterol (mg/dL)							P for trend
	<30	30-39.9	40-49.9	50-59.9	60-69.9	70-79.9	≥80
Age
<60 years	1.00	0.84 (0.71-1.01)	0.68 (0.56-0.83)	0.66 (0.52-0.84)	0.74 (0.54-1.01)	0.44 (0.25-0.78)	0.48 (0.27-0.88)	<0.001
≥60 years	1.00	0.88 (0.81-0.94)	0.80 (0.74-0.87)	0.72 (0.65-0.79)	0.71 (0.63-0.80)	0.81 (0.69-0.96)	0.70 (0.56-0.88)	<0.001
Race
African American	1.00	0.87 (0.77-0.99)	0.84 (0.74-0.95)	0.77 (0.67-0.89)	0.82 (0.69-0.97)	0.83 (0.66-1.04)	0.72 (0.55-0.95)	0.026
White	1.00	0.90 (0.82-0.97)	0.79 (0.72-0.87)	0.73 (0.65-0.81)	0.70 (0.60-0.82)	0.76 (0.60-0.96)	0.67 (0.48-0.94)	<0.001
Body mass index
<30 kg/m2	1.00	0.83 (0.74-0.93)	0.79 (0.70-0.89)	0.72 (0.63-0.82)	0.71 (0.60-0.84)	0.80 (0.64-1.00)	0.74 (0.57-0.96)	<0.001
≥30 kg/m2	1.00	0.93 (0.85-1.01)	0.82 (0.74-0.90)	0.76 (0.68-0.86)	0.82 (0.70-0.96)	0.82 (0.64-1.04)	0.64 (0.44-0.94)	<0.001
HbA1c
<7%	1.00	0.81 (0.73-0.90)	0.75 (0.67-0.83)	0.69 (0.61-0.78)	0.73 (0.62-0.85)	0.79 (0.64-0.98)	0.70 (0.53-0.91)	<0.001
≥7%	1.00	0.96 (0.87-1.05)	0.87 (0.78-0.96)	0.80 (0.71-0.90)	0.77 (0.65-0.91)	0.75 (0.58-0.97)	0.66 (0.47-0.92)	<0.001
Smoking status
Never smoking	1.00	0.84 (0.77-0.91)	0.75 (0.69-0.82)	0.69 (0.62-0.76)	0.69 (0.60-0.78)	0.68 (0.56-0.83)	0.53 (0.40-0.71)	<0.001
Current and past smoking	1.00	0.88 (0.78-1.01)	0.79 (0.68-0.91)	0.68 (0.57-0.81)	0.70 (0.56-0.87)	0.95 (0.71-1.28)	0.95 (0.69-1.31)	<0.001
Anti-diabetic medications
No use	1.00	0.74 (0.64-0.85)	0.72 (0.62-0.83)	0.66 (0.56-0.78)	0.61 (0.50-0.75)	0.61 (0.45-0.82)	0.62 (0.44-0.88)	<0.001
Oral agents	1.00	0.90 (0.79-1.04)	0.78 (0.67-0.90)	0.72 (0.61-0.85)	0.84 (0.69-1.04)	0.95 (0.72-1.26)	0.56 (0.36-0.90)	<0.001
Insulin	1.00	1.02 (0.93-1.12)	0.94 (0.84-1.05)	0.85 (0.75-0.98)	0.81 (0.68-0.97)	0.81 (0.61-1.06)	0.79 (0.58-1.09)	0.009
Lipid-lowering medications
No use	1.00	0.86 (0.76-0.97)	0.79 (0.69-0.90)	0.67 (0.57-0.79)	0.72 (0.59-0.88)	0.68 (0.51-0.91)	0.75 (0.55-1.02)	<0.001
Use	1.00	0.91 (0.84-0.99)	0.83 (0.76-0.91)	0.78 (0.70-0.87)	0.79 (0.69-0.91)	0.87 (0.72-1.06)	0.67 (0.51-0.90)	<0.001
Anti-hypertensive medications
No use	1.00	0.79 (0.65-0.96)	0.77 (0.63-0.95)	0.69 (0.54-0.88)	0.69 (0.51-0.94)	0.70 (0.46-1.08)	0.84 (0.52-1.33)	0.095
Use	1.00	0.90 (0.84-0.97)	0.82 (0.75-0.88)	0.75 (0.69-0.83)	0.77 (0.68-0.87)	0.82 (0.69-0.97)	0.67 (0.53-0.85)	<0.001

Data are hazard ratios (95% confidence intervals) unless otherwise indicated. Adjusted for age, race, sex, body mass index, systolic blood pressure, HbA1c, low-density lipoprotein cholesterol, triglycerides, estimated GFR, smoking, use of antihypertensive drugs, use of diabetes medications, and use of lipid-lowering agents, other than the variables for stratification.

All P for interaction >0.25.