Fig. 2.

HSV-1 entry glycoproteins and their known receptors. Initial interactions of HSV envelope glycoproteins gB and/or gC with heparan sulfate proteoglycans (HSPG) occur on the surface of a host cell, which facilitate viral attachment and surfing on membrane projections to reach the plasma membrane. This is followed by specific interactions of HSV gD and gB with their corresponding receptors leading to membrane fusion and delivery of the viral nucleocapsid and tegument proteins into the cytoplasm