Table 5:

Prognostic factors of slow healing (> 29 days) of microbial keratitis cases from Saint Louis (1999–2013)

All Cases (N=183)	Univariate logistic regression			Mutivariate logistic regression
Prognostic factors	OR	95% CI	p-value#	OR	95% CI	p-value
Age ≥ 60 years	0.85	0.45–1.60	1
Large ulcers > 5 mm	4.95	2.38–10.27	< .01	6.38	2.90–14.06	< .001
Pseudomonas sp.	1.48	0.77–2.84	1
Fungi/acanthamoeba	4.67	1.99–10.92	< .01	5.05	2.03–12.55	< .001
Tertiary referred cases	2.51	1.33–4.72	.028
Prior ophthalmic steroid use	0.77	0.40–1.47	1
Co-morbid ocular conditions§	0.47	0.26–0.86	.098	0.44	0.22–0.87	.018*
Bacteria-only cases (N=153)
Age ≥ 60 years	1.04	0.52–2.11	1
Large ulcers > 5 mm	6.09	2.73–13.55	< .01	6.76	2.95–15.51	< .001
Pseudomonas sp.	2.35	1.17–4.74	.102
Tertiary referred cases	1.83	0.89–3.78	.618
Prior ophthalmic steroid use	0.49	0.22–1.09	.48
Co-morbid ocular conditions§	0.53	0.27–1.05	.408	0.44	0.21–0.93	.033*

OR = odds ratio

CI = confidence interval

^#Bonferroni corrected p-values

^§Including prior ophthalmic surgery and pre-existing ocular surface disease

^*co-morbid ocular conditions are statistically correlated in a negative fashion