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Timeline of major renal manifestations and treatment in patients with adenine phosphoribosyltransferase deficiency according to age below or above 18 years at diagnosis. Year of birth is shown on the Y-axis. Age at initiation of xanthine oxidoreductase inhibitor (allopurinol or febuxostat) treatment is indicated within each patientߣs timeline. The patient born in the year 1967 did not receive drug treatment prior to progressing to kidney failure.
