Table 1.

Tolerance Induction Regimens

	Medical Center
Patients and Outcomes	Northwestern University*	Stanford University	Massachussetts General Hospital	Samsung Medical Center
HLA matched or mismatched	mismatched	matched/mismatched	mismatched	mismatched
Recipient conditioning regimen	TBI+CY+Flu	TLI+ATG/TLI+ATG	LTI+CY+anti-CD2mAb	CY+ATG
Donor cell composition	mobilized blood CD34 cells + T cells + facilitator cells	mobilized blood CD34 cells + T cells	whole bone marrow	whole bone marrow
No. patients enrolled and given kidney transplants	37	29/19	10	7
No. patients with withdrawal of IS drugs attempted	22	24/6**	7	4
No. patients continuously off IS drugs	22	21/0	4	2
Duration continuously off IS drugs	8–81 mos		84–168 mos	25–35 mos
No. patients off IS drugs with return to IS drugs due to rejection or relapse	0	3/2	3	2
Duration off IS drugs before return to IS drugs	-	12–63 mos/3–5 mos	48–84 mos	2–16 mos

TBI-200 cGy total body irradiation; TLI-80–120 cGyx10 doses total lymphoid irradiation; CY-cyclophosphamide; ATG-anti-thymocyte globulin; Flu-fluorabine; CD34 cells; G-CSF; mobilized blood with enriched hematopoietic progenitor T cells from immobilized blood, mAb-monoclonal antibody, LTI-700cGy local thymic irradiation.

^*One of 37 recipients was enrolled and transplanted at Duke University

^**4 patients returned to therapeutic levels of Tac after loss of chimerism