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. 2019 Jan 22;13:6. doi: 10.3389/fnins.2019.00006

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Copyright © 2019 Guo, Duan, Chen, Wang, Wang, Shen, Qi, Jiang, Zhu, Xi, Lü and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferation of OPCs in the injured spinal cord post-SCI, as determined by BrdU incorporation. (A,B) Representative photomicrographs showing BrdU+ cells (green) co-localized with O4+OPCs (red) in the circumambience of the injured spinal cord of rats at 2 and 6 weeks post-SCI. (C,D) Quantitative analysis of OPC proliferation, demonstrating an increase in both the number and percentage of BrdU+OPCs in rats that received PDGF-AA versus controls. Data represent the mean ± SD (n = 8). ^∗P < 0.05; ^∗∗P < 0.01. Scale bar = 20 μm.