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. 2019 Jan 22;9:743. doi: 10.3389/fpsyt.2018.00743

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Copyright © 2019 He, Vinkers, Houtepen, de Witte and Boks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of KITLG (cg26512205) methylation level with childhood adversity in both healthy controls (blue dots) and bipolar disorder patients (red square). Y-axis is the beta value of KITLG (cg26512205) methylation level after adjustment for cell type composition, age, gender and smoking. X-axis is the childhood adversity score. Significant positive association between childhood adversity and KITLG methylation was present in the healthy individuals (b = 0.012, p = 0.002). No significant association between KITLG methylation and childhood adversity in the bipolar disorder patients was present (b = 0.004, t = 1.039, p = 0.304).