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. 2019 Jan 22;11:3. doi: 10.3389/fnagi.2019.00003

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Copyright © 2019 Wang, Xia, Shen, Zhou, Wu, Shi, Xu, Hou, Zhang, Qiu, Xie, Chen, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of BIS-MEP on β-amyloid (Aβ) plaques in the brains of AD model mice. (A) Images of immunohistochemical staining for Aβ deposition in representative sections of the hippocampus from each group (40× magnification). Aβ was labeled with the 6E10 antibody. Aβ plaques are marked with black triangles. Representative images captured at 100× magnification are shown for specification. (B) The quantitative analysis of the percentage of Aβ plaque areas. Image-Pro Plus software was used to semi-quantitatively measure the percentage of plaque areas. Bars in the chart represent the means ± SEM for each group (n = 7–10). Significant differences between the AD model group and other groups are indicated by asterisks, and differences between BIS-MEP H group and Donepezil group are indicated by the pound sign. *P < 0.05, **P < 0.01, ***P < 0.001, and ^#P < 0.05.