Table 1.
List of genes associated with Common variable immunodeficiency (monogenic causes and modifier genes) and their prevalence, adjusted according to Bogaert et al. (8).
| Gene | Prevalence (%) |
|---|---|
| MONOGENIC CAUSE OF CVID: 2–10% | |
| PIK3CD | 26.74 |
| LRBA | 26.74 |
| CTLA4 | 6.42 |
| NFKB2 | 5.35 |
| TNFRSF7 (CD27) | 4.81 |
| PIK3R1 | 4.81 |
| ICOS | 3.74 |
| CD19 | 3.74 |
| IL-21R | 3.21 |
| IKZF1 (IKAROS) | 3.21 |
| PRKCD | 2.14 |
| PLCG2 | 2.14 |
| NFKB1 | 1.6 |
| CR2 (CD21) | 1.7 |
| MODIFIER GENES: UNKNOWN PREVALENCE | |
| TNFRSF13B (TACI), TNFRSF13C (BAFF-R), MSH2, MSH5, CLECG1, MLH1, RAD50, ORC4L, FCGR2A. | |