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. 2019 Jan 22;9:1196. doi: 10.3389/fneur.2018.01196

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Copyright © 2019 Sadeghi, Sabetazad, Rassaian and Sadeghi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unidirectional rotational rehabilitation resulted in long-term improvement of VOR asymmetry. Data points are from subjects who participated in at least 2 session (n = 6) and the initial values measured before rehabilitation are shown for each session. DP decreased over time for the majority of these subjects (A). The only significant change is between the DP for the first session compared to other sessions (ANOVA, p < 0.01), suggesting that the decrease in asymmetry occurs in the first couple of sessions for most subjects. This decrease was due to a decrease in VOR responses to HA rotations (B) as well as an increase in responses to LA rotations (C). Changes in VOR responses (i.e., eye velocities or gains) were not significant, but were enough to result in a highly significant improvement in VOR symmetry, as quantified by DP. Note the increase in VOR responses for both sides in the final session, reaching close to normal values (~40°/s).