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. 2019 Jan 22;10:4. doi: 10.3389/fphar.2019.00004

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Copyright © 2019 Tian, Pan, Zhang, Qu, Lian, Jiang, Gao and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of tumor growth by injection of physiological saline (control), blank GH-DPP nanoparticles, free DOX, siRNA/DPP, DOX/DPP, siRNA/DOX/DPP or siRNA/DOX/GH-DPP nanoparticles, respectively. (A) Tumor growth curves; (B) Body weight changes; (C) The tumor growth inhibition rate; (D) excised tumors of each group; (E) Histological observation of heart for H22 tumor-bearing mice treated with different drug formulations; (F) The histological features of H22 subcutaneous tumor sections are characterized by H and E and BCL-2 immunohistochemical analysis. The data represent the mean of the tumor volume or body weight from five mice ± SD; ^∗P < 0.05 and ^∗∗P < 0.01.