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cDC and monocyte migration toward lung TLOs. (A) cDCs and monocytes are decreased in circulation of IPAH patients due to migration to the lungs in which cDCs and monocytes are increased. (B) In the lung they can add to the development of TLOs surrounding PAs. (C) TLOs consist, besides DCs, of different immune cells such as T-cells, B-cells, macrophages, and granulocytes.
