Table 1.

Target whole blood concentrations and predicted plasma concentrations for tacrolimus using different hematocrit values

	Time post-transplantation	Target range wba (μg/l)	Predicted target range plasma (μg/l)	Predicted target range wb (μg/l)	Predicted target range wb (μg/l)
		literature Ht = 0.35	literature Ht = 0.35	Ht = 0.30	Ht = 0.25
Target trough level (C0) prednisolone-free regimen	0–4 weeks	10–20	0.27–0.58	8.6–17.2	7.2–14.5
	4 weeks–6 months	5–15	0.13–0.42	4.3–12.9	3.6–10.8
	6–12 months	5–10	0.13–0.27	4.3–8.6	3.6–7.2
	> 12 months	4–8	0.10–0.21	3.4–6.9	2.9–5.8
Target trough level (C0) immunosuppressive regimen including prednisolone	0–4 weeks	10–15	0.27–0.42	8.6–12.9	7.2–10.8
	4 weeks–6 months	7–12	0.19–0.33	6.0–10.3	5.1–8.7
	6–12 months	5–10	0.13–0.27	4.3–8.6	3.6–7.2
	> 12 months	4–8	0.10–0.21	3.4–6.9	2.9–5.8

AUC area under the concentration time curve, C₀ trough concentration, wb whole blood

^aTargets according to our local hospital protocol which is based on the following references: [23, 3, 24, 11]