Figure 5.

D- Rag KO mice develop a severe and lethal C. rodentium infection. (A) IL-22 secreting ILC3 frequencies in the colon of D- and D+ Rag KO mice. (B) C. rodentium fecal shedding in D+ and D- Rag KO mice. (C) Survival curves following C. rodentium infection of D+ and D- Rag KO mice. Values are from n = 6–7 D+ Rag KO and n = 6 D- Rag KO mice of two combined experiments. Significance was determined by two-tailed Student's t tests (A), two-way ANOVA with Bonferroni post-hoc tests (B) or log rank tests for (C), ^*P < 0.05, ^**P < 0.01.