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. 2019 Jan 22;10:1. doi: 10.3389/fimmu.2019.00001

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Copyright © 2019 Lin, Arora, Diehl, Bora and Cantorna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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1, 25D treatment and IL-22 treatment of D- mice resulted in more rapid clearance of C. rodentium infection. (A) Frequencies of ILC3 cells in the colon of D- mice treated with 1, 25D. (B) Frequency of IL-22 secreting ILC3 cells following 1, 25D treatment. C. rodentium fecal shedding in D- WT mice treated with (C) 1,25D (D- + 1,25D) or (D) IL-22 treated (D- + IL-22Fc). Values are mean ± SEM of two combined experiments and (A) n = 7–19 (B) n = 8–11 (C) n = 4 (D) n = 6–9 mice per group. Significance was determined using two-tailed Student's t tests (A,B), two-way ANOVA with Tukey post-hoc tests (C,D).