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. 2019 Jan 28;10:453. doi: 10.1038/s41467-019-08315-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Proposed model. Our data support a model in which vein-enriched bone morphogenetic protein (BMP) ligands BMP2 and BMP4 signal through the vein-specific Alk3 type I receptor (in combination with multiple different BMP type II receptors) resulting in the phosphorylation of SMAD1/5, transcriptional activation of the Ephb4 and Coup-TFII genes and subsequent venous identity