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. 2019 Jan 28;9:773. doi: 10.1038/s41598-018-37299-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduced hepatic gene expression for lipogenesis mediators in DNT5 mice. All data were from mice which had been provided with western-style diet and DOX for 12 weeks. All mice were ApoE^−/−. (A) Example liver sections stained with H&E. Scale bar 100 μm. (B) Comparison of lipid content (steatosis) between Controls and DNT5. On the left, Mann-Whitney analysis showing mean and s.e.m (N = 11 Control, N = 14 DNT5). On the right, linear random effects model showing the standardised mean difference and confidence intervals. Data below the zero line indicate decrease in the DNT5 group (n/N = 8/11 Control, n/N = 8/13 DNT5). (C) All data were from quantitative real-time PCR analysis of liver RNA. Comparison of expression of sterol regulatory element-binding protein 1c gene (Srebp1c), acetyl-CoA carboxylase 1 gene (Acaca), fatty acid synthase gene (Fasn) and stearoyl-CoA desaturase 1 gene (Scd1) mRNA abundance between Controls and DNT5. On the left, Mann-Whitney analysis showing mean and s.e.m (N = 11 Control, N = 14 DNT5). On the right linear random effects model showing the standardised mean difference and confidence intervals. Data below the zero line indicate decrease in the DNT5 group (n/N = 8/11 Control, n/N = 8/13 DNT5). (D) Comparison of non-fasting plasma concentrations of cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides between Controls and DNT5 after 12 weeks of western-style diet and DOX administration. On the left, Mann-Whitney analysis showing mean and s.e.m (N = 11 Control, N = 14 DNT5). On the right, linear random effects model showing the standardised mean difference and confidence intervals (n/N = 8/11 Control, n/N = 8/14 DNT5).