Table 2.
ANOVA with Bonferroni correction showed that plasma CoQ values were significantly lower in the PKU and MPS groups than in controls.
| Group (I) | Groups (J) | Average difference (I-J) | 95% confidence interval |
|---|---|---|---|
| CoQ | |||
| Controls | PKU | 0.164 | 0.067–0.261 (p < 0.0001) |
| MPS | 0.252 | 0.127–0.377 (p < 0.0001) | |
| IEM | 0.100 | −0.013–0.213 (p = 0.139) | |
| CoQ/Chol | |||
| Controls | PKU | 31.6 | 11.4–51.8 (p < 0.0001) |
| MPS | 69.4 | 38.9–99.9 (p < 0.0001) | |
| IEM | 24.1 | 0.4–47.8 (p = 0.043) | |
| MPS | PKU | −37.8 | −67.4 – −8.4 (P = 0.003) |
| IEM | −45.3 | −77.3–13.4 (p = 0.001) | |
IEM group showed intermediate values that were not significantly different from those of the controls. When we compared the CoQ/Chol ratios in these 3 groups, MPS values were significantly lower than controls, PKU, and IEM. In turn, IEM and PKU patients showed significantly lower values than controls.