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. 2019 Jan 28;9:800. doi: 10.1038/s41598-018-37280-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Charge distribution at the protruding nose end of native and K35E IL-2. Native IL-2 is represented in panel a, and its K35E mutated variant is shown in panel b. Protein backbones are represented as cartoons in grey. Charged residues at the protruding nose end of IL-2 cylinder are represented with coloured sticks in and labelled. Positively charged residues are in red, while the negatively charged Glu is blue.