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. 2019 Jan 28;9:797. doi: 10.1038/s41598-018-37545-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship with Conventional PD Subtypes. (A) Patient correlation of three subtypes and motor subtypes at baseline, median time point, and 6-year follow-up. Patients are categorized into motor subtypes including TD, PIGD, and Indeterminate. The longitudinal correlation of three subtypes with TD and PIGD are plotted by lines respectively. (B) Patient correlation of three subtypes and cognitive subtypes at baseline, median time point, and 6-year follow-up. Patients are categorized into cognitive subtypes including Normal Cognition (PD-NC), Mild Cognitive Impairment (PD-MCI), and Dementia (PDD). The longitudinal correlation of three subtypes with PD-NC, PD-MCI, and PDD are plotted by lines respectively. (C) Patient correlation of three subtypes and mood subtypes at baseline, median time point, and 6-year follow-up. Patients are categorized into mood subtypes including Anxiety, Depression, Depression-Anxiety (DA), and Normal Mood. The longitudinal correlation of three subtypes with Anxiety, Depression, and Anxiety-Depression are plotted by lines respectively.