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. 2019 Jan 28;9:810. doi: 10.1038/s41598-018-37123-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-culture media analyses at each prescribed time point after immersion of nHA_100, nHA_400, mHA_100, and mHA_400 coated Mg plates, non-coated Mg plate control in rSBF, and rSBF control for 6 weeks. Mg plate samples had a dimension of 7.5 mm in diameter and 1 mm in thickness. (a) The pH of the collected rSBF after cultured with each sample at each prescribed time point. (b) The Mg²⁺ ion concentration in the collected rSBF after cultured with each sample at each prescribed time point. (c) The Ca²⁺ ion concentration in the collected rSBF after cultured with each sample at each prescribed time point. Data are mean ± standard error (N = 3).