Fig. 6. High cholesterol diet (HCD) did not alter doublecortin (DCX) positive neuroblasts in the subventricular zone (SVZ), but the area occupied by these cells was dramatically increased by simvastatin (SV) in TGF fed a HCD.

A small cluster of DCX-immunostained neuroblasts (Cy3, red) was found in the rostral migratory stream (open arrow) of the SVZ in WT and TGF mice treated or not with a HCD. The surface area occupied by DCX-labelled cells in the corpus callosum (cc) was significantly larger in HCD-fed TGF mice concurrently treated with SV. The area of analysis is depicted by the white rectangle (left top panel). CTX cerebral cortex; LV lateral ventricle. Bar: 300 μm, **p < 0.01