Fig. 2.

Napepld^∆IEC are hyperphagic upon early HFD exposure without changes in energy expenditure. a HFD intake (Kcal) after 24 h and 5 days of feeding (n = 9–10). b Light and dark cycle energy expenditure (Kcal h⁻¹ Kg body weight⁻¹) measured in metabolic chambers during indirect calorimetry studies. c Light and dark cycle of CO₂ production (l h⁻¹ Kg body weight⁻¹). d Light and dark cycle of O₂ consumption (l h⁻¹ kg body weight⁻¹). Purple: WT HFD mice and pink: Napepld^∆IEC HFD mice. Data are presented as the mean ± s.e.m. * and ** indicate a significant difference versus WT HFD (Respectively P < 0.05 and P < 0.01) according to Mann–Whitney test