Figure 8.

Nanoparticle uptake by MDA-MB 231 cells. The top panels (scatter plots) show single-cell fluorescence of internalized nanoparticles (black) for four different nanoparticle sizes (diameters): (A) 26 nm, (B) 47 nm, (C) 100 nm, and (D) 200 nm. In the panels, black and red points represent experimental data and model prediction (after fitting), respectively. The solid lines represent the deterministic predictions (σ_t = 0). The experimental data (fluorescence of cell-internalized particles) are presented after normalizing with a bead fluorescence. The model predictions are scaled with a constant value (free parameter) to fit the normalized fluorescence data. The lower panels (histograms) show the cellular distribution of particle uptake for the four particle sizes. In each panel, black, red, and green refer to the internalized particle fluorescence, the model predicted uptake, and control cell fluorescence, respectively. To see this figure in color, go online.