Figure 3.

The effect of N-terminus-bound fluorophores on oligomer size distributions of Aβ40 at low DOL. (A) Chemical structures as provided by the manufacturer (Atto dyes) or by (38) and (20) for HL488 and HL647, (B) oligomer size distributions in terms of relative photon numbers $N_{phot,rel}=N_{phot}/{\overline{N}}_{phot,mon}$ of labeled Aβ40 peptides (DOL 5%) after 4 and 24 h, (C) fluorescence lifetime distributions before and after 4 h of fibrillation, and (D) time-dependent anisotropy of the fluorescent labels before fibrillation. To see this figure in color, go online.