Figure 5.

Articular cartilage regeneration 6 months after the treatment with TGFβ1/BMP-4-affinity-bound bilayered alginate hydrogel. Macroscopic appearance of the defects after (A) treatment with GF-loaded hydrogel or (B) after the treatment with empty hydrogel. Dotted circle represents defect borders. Note similarity in tissue appearance to surrounding cartilage in the defects treated with affinity-bound GF-loaded alginate hydrogel.

BMP-4 = bone morphogenic protein 4; TGFβ1 = transforming growth factor-β1.