Table 4.

BMPR2, ACVRL1, and SMAD9 gene haplotypes and EH Risk

Gene	Haplotype	Case (n=460)	Control (n=460)	OR (95% CI)	P value	Adjusted OR (95% CI)	Adjusted P value
BMPR2	CG	0.215	0.523	0.249 (0.185–0.336)	<0.001	0.468 (0.390–0.557)	<0.001
	TT	0.412	0.235	2.294 (1.291–1.658)	<0.001	1.469 (1.291–1.658)	<0.001
	CT	0.354	0.401	0.823 (0.625–1.085)	0.153	0.906 (0.785–1.041)	0.174
ACVRL1	CC	0.254	0.324	0.712 (0.529–0.958)	0.020	0.839 (0.712–0.979)	0.024
SMAD9	CC	0.308	0.381	0.727 (0.548–0.965)	0.022	0.849 (0.730–0.982)	0.026
	TC	0.326	0.343	0.925 (0.697–1.228)	0.576	0.961 (0.830–1.106)	0.625

Abbreviations: Acc, accuracy; Bac, balanced; CI, confidence interval; CV, cross-validation; OR, odds ratio.