Table 2b.
Relationship Between Stromal (s) and Intratumoral (i) CD4 and CD8 Lymphocytes and Clinicopathological Characteristics
| Characteristics | sCD4 |
iCD4 |
sCD8 |
iCD8 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative |
Positive |
P | Negative |
Positive |
P | Negative |
Positive |
P | Negative |
Positive |
P | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||
| Age | ||||||||||||
| ≤ 57 | 35 (43.8) | 53 (63.9) | .1569 | 49 (57) | 38 (49.4) | .9174 | 35 (41.7) | 53 (61.6) | .1479 | 43 (52.4) | 46 (51.7) | 1.0000 |
| > 57 | 45 (56.2) | 30 (36.1) | 37 (43) | 39 (50.6) | 49 (58.3) | 33 (38.4) | 39 (47.6) | 43 (48.3) | ||||
| Histological type | ||||||||||||
| IDC | 70 (87.5) | 69 (83.1) | .0781 | 71 (82.5) | 67 (87) | .6520 | 68 (81) | 74 (86.1) | .6536 | 70 (85.4) | 73 (82) | .5117 |
| ILC | 8 (10) | 5 (6) | 9 (10.5) | 5 (6.5) | 10 (11.9) | 7 (8.1) | 6 (7.3) | 11 (12.4) | ||||
| Other | 2 (2.5) | 9 (10.9) | 6 (7) | 5 (6.5) | 6 (7.1) | 5 (5.8) | 6 (7.3) | 5 (5.6) | ||||
| Tumor size (cm) | ||||||||||||
| ≤ 2 cm | 42 (53.2) | 58 (70.7) | .0216 | 57 (67.1) | 43 (56.6) | .1712 | 53 (63.1) | 56 (65.9) | .7050 | 62 (75.6) | 47 (53.4) | .0026 |
| > 2 cm | 37 (46.8) | 24 (29.3) | 28 (32.9) | 33 (43.4) | 31 (36.9) | 29 (34.1) | 20 (24.4) | 41 (46.6) | ||||
| Lymph node status | ||||||||||||
| Negative | 53 (67.1) | 46 (56.1) | .1519 | 54 (62.8) | 45 (60) | .7166 | 52 (61.9) | 52 (61.9) | 1.0000 | 54 (65.9) | 50 (53.2) | .0883 |
| Positive | 26 (32.9) | 36 (43.9) | 32 (37.2) | 30 (40) | 32 (38.1) | 32 (38.1) | 28 (34.1) | 44 (46.8) | ||||
| Histological grade | ||||||||||||
| G1 | 4 (5.1) | 7 (8.6) | .1624 | 8 (9.5) | 4 (4.7) | .4442 | 6 (7.3) | 8 (9.5) | .6145 | 9 (11) | 5 (5.9) | .0039 |
| G2 | 51 (65.4) | 41 (50.6) | 50 (59.5) | 51 (60) | 51 (62.2) | 46 (54.8) | 56 (68.3) | 42 (49.4) | ||||
| G3 | 23 (29.5) | 33 (40.8) | 26 (30.9) | 30 (35.3) | 25 (30.5) | 30 (35.7) | 17 (20.7) | 38 (44.7) | ||||
| Receptor status | ||||||||||||
| ER-negative(≤10%) | 8 (10) | 22 (27.2) | .0052 | 21 (24.7) | 10 (13.2) | .0636 | 9 (10.7) | 21 (25) | .0156 | 17 (21) | 13 (14.8) | .2908 |
| ER-positive (>10%) | 72 (90) | 59 (72.8) | 64 (75.3) | 66 (86.8) | 75 (89.3) | 63 (75) | 64 (79) | 75 (85.2) | ||||
| PgR-negative (≤10%) | 22 (27.5) | 34 (42) | .0538 | 35 (41.2) | 21 (27.6) | .0716 | 27 (32.1) | 35 (41.7) | .2009 | 34 (42) | 28 (31.8) | .1711 |
| PgR-positive (> 10%) | 58 (72.5) | 47 (58) | 50 (58.2) | 55 (72.4) | 57 (67.9) | 49 (58.3) | 47 (58) | 60 (68.2) | ||||
| MIB1 | ||||||||||||
| Negative (≤20%) | 59 (73.8) | 46 (56.8) | .0239 | 59 (69.4) | 46 (60.5) | .2373 | 61 (72.6) | 53 (63.1) | .1863 | 62 (76.5) | 53 (60.2) | .0231 |
| Positive (> 20%) | 21 (26.2) | 35 (43.2) | 26 (30.6) | 30 (39.5) | 23 (27.4) | 31 (36.9) | 19 (23.5) | 35 (39.8) | ||||
| HER2/neu | ||||||||||||
| Negative (0.1+) | 72 (90) | 62 (77.5) | .0321 | 73 (86.9) | 61 (80.3) | .2555 | 73 (86.9) | 68 (81.9) | .3751 | 71 (87.7) | 71 (81.6) | .2790 |
| Positive (3+) | 8 (10) | 18 (22.5) | 11 (13.1) | 15 (19.7) | 11 (13.1) | 15 (18.1) | 10 (12.3) | 16 (18.4) | ||||